|
Mol Cell Endocrinol
2010
Aug
; 324
( 1-2
): 110-20
Neuroendocrine disruption of pubertal timing and interactions between homeostasis of reproduction and energy balance.
| Bourguignon
JP
, Rasier
G
, Lebrethon
MC
, Gérard
A
, Naveau
E
, Parent
AS
| Developmental Neuroendocrinology Unit, GIGA Neurosciences, University of Liège and Department of Pediatrics, CHU de Liège, Belgium. jpbourguignon@ulg.ac.be
|
The involvement of environmental factors such as endocrine disrupting chemicals (EDCs) in the timing of onset of puberty is suggested by recent changes in age at onset of puberty and pattern of distribution that are variable among countries, as well as new forms of sexual precocity after migration. However, the evidence of association between early or late pubertal timing and exposure to EDCs is weak in humans, possibly due to heterogeneity of effects likely involving mixtures and incapacity to assess fetal or neonatal exposure retrospectively. The neuroendocrine system which is crucial for physiological onset of puberty is targeted by EDCs. These compounds also act directly in the gonads and peripheral sex-steroid sensitive tissues. Feedbacks add to the complexity of regulation so that changes in pubertal timing caused by EDCs can involve both central and peripheral mechanisms. In experimental conditions, several neuroendocrine endpoints are affected by EDCs though only few studies including from our laboratory aimed at EDC involvement in the pathophysiology of early sexual maturation. Recent observations support the concept that EDC cause disturbed energy balance and account for the obesity epidemic. Several aspects are linking this system and the reproductive axis: coexisting neuroendocrine and peripheral effects, dependency on fetal/neonatal programming and the many factors cross-linking the two systems, for instance leptin, adiponectin, Agouti Related Peptide (AgRP). This opens perspectives for future research and, hopefully, measures preventing the disturbances of homeostasis caused by EDCs.
PMID: 20206664 [PubMed - in process] Click HERE for the full article |
